What do you want to do? Spring break is quite crowded with the major area's. Be prepaird for bugs, crowds and STRONG sun.
Link -
http://www.cruisersnet.net/index.php click on the side bar for areas.
Sometimes the wind and rain will last all week long or at least 2 to 3 days. One needs to plan for that.
Temps - just a few degrees differance north and south, it depends on what you have been through.
Someplace nice and calm, Do the Okeechobee waterway. Park at any of the lock camp sites. It can get crowed so have 2 anchors, bow and stern.
A little more extreme is the Everglades.
Juat want to hang on the boat and have an Island, Cayo Costa north of Ft Myers.
Marathon in the Keys, anchor on the other side of the bridge.
Check the KOA's in the Keys for truck storage and boat storage.
Tampa Bay is nice as well.
If you have a good dinghy and can handle a mooring ball, John Pennycamp in Kay Largo is good, To much traffic at the dock. Call first.
Get some cruising guides, When the weather is nice I have never had a bad spot.